But compared with almost every other form of transport, aviation is extremely safe, and with barely a month remaining 2016 may end with one of the lowest death tolls on record.
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While many accidents are survivable – such as the Emirates crash in Dubai in August, when all 300 people on board escaped – some are not.
Each victim represents a terrible tragedy for their family and friends.
The second was Egyptair flight 804 from Paris to Cairo in May, in which 66 people died when the Airbus A320 came down in the Mediterranean.
In addition there have been two crashes of passenger propeller planes on domestic flights: a Sunbird Aviation crash in Papua New Guinea, when 13 lives were lost, and a Tara Air flight in Nepal, in which 23 people died.